CLINICAL ACTIONS: The NICHD conducted a workshop in January to review evidence, with special consideration to avoid unnecessary. The American College of Obstetricians and Gynecologists (ACOG) published a Intraamniotic infection, also known as chorioamnionitis, is an. Historically, infection of the chorion, amnion, or both was termed ” chorioamnionitis.” Although this term remains in common use, the term.

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Evidence from randomized trials and observational studies demonstrate that immediate intrapartum use of broad-spectrum antibiotics significantly reduces maternal and fetal complications of chorioamnionitis [ cjorioamnionitis — 83 ].

This information should not be considered as inclusive of all proper treatments or methods of care or as a statement of the standard of care.

The Centers for Disease Control and Prevention and the American Academy of Pediatrics provide guidelines for assessing risk of neonatal infection 7, 35— Therefore, until better and less invasive intrapartum diagnostic tools become available, any practical distinction between suspected and confirmed intraamniotic infection will remain meaningful only in research settings and not for the obstetrician—gynecologist or other obstetric care provider managing a patient in labor.

The increase in postpartum hemorrhage appears to be due to dysfunctional uterine muscle contractions as a result of inflammation [ 54 — 55 ]. Maternal and perinatal outcome of expectant management of premature rupture of membranes in the midtrimester. Dev Med Child Neurol. Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates.

Women’s Health Care Physicians

Intraamniotic infection also can occur, although rarely, after invasive procedures eg, amniocentesis or chorionic villus sampling or by a hematogenous route secondary to maternal systemic infection eg, Listeria monocytogenes.

The value of the soluable intercellular adhesion molecule-1 levels in matermal serum for determination of occult chorioamnionitis in premature rupture of membranes. The protective effect of maternal intrapartum antibiotic administration has been demonstrated in recent multivariate risk models of individual infant risk of ackg sepsis 5, Comparison of gram stain, leukocyte esterase activity, and amniotic fluid glucose concentration in predicting amniotic fluid culture results in preterm premature rupture of membranes.

If cesarean delivery is performed, clindamycin every 8 hours or metronidazole is often added for anaerobic coverage. Histologic chorioamnionitis captures sub-clinical as well as clinical chorioamnionitis, thus it is not surprising that overall histologic chorioamnionitis at term is up to 3 times as frequent as clinical chorioamnionitis confirmed by amniotic fluid culture [ 47 ].


In the intrapartum patient with an epidural and low-grade fever without tachycardia maternal or fetal or other clinical signs of intrauterine inflammation, epidural-associated fever is a strong consideration. This information is designed as an educational resource to aid clinicians in providing obstetric and gynecologic care, and use of chorioamnilnitis information is voluntary.

Effect of early-onset sepsis evaluations on in-hospital breastfeeding practices among asymptomatic term neonates. Am J Obstet Gynecol ; AndrewsPhD, MD b. Treating intrapartum fever with antipyretics may also be helpful in reducing fetal tachycardia thereby avoiding cnorioamnionitis tendency to perform cesarean for a non-reassuring fetal status.

Generally non-specific [ 4 ]. Leukocyte esterase activity in amniotic fluid: Dev Med Child Neurol ; Recent data on the development of the neonatal microbiome and the role of early antibiotic exposures suggest that antibiotic therapy may not be entirely benign 39— Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: Timely maternal management together with notification of the neonatal health care providers will facilitate appropriate evaluation and empiric antibiotic treatment when indicated.

Non-infectious conditions associated with abdominal pain usually in absence of fever include thrombophlebitis, round ligament pain, colitis, connective tissue disorders and placental abruption. Value of the maternal interleukin 6 level for determination of histologic chorioamnionitis in preterm chotioamnionitis.

Chorioamnionitis that is subclinical by definition does not present the above clinical signs but may manifest as preterm labor or, even more commonly, as preterm premature rupture of membranes PPROM.

Cell Host Microbe ; Support Center Support Center. The use of intrapartum antibiotic treatment given either in response to maternal group B streptococcal colonization or in response to evolving signs of intraamniotic chorioamnionigis during labor has been associated with a nearly fold decrease in group B streptococcal-specific neonatal sepsis 6—8.

Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery. Andrews b Charles E. Although PPROM is a major risk factor for clinical chorioamnionitis, it is noteworthy that together with preterm labor, PPROM frequently is the consequence of sub-clinical chorioamanionitis [ 21 ]. Clinical chorioamnionitis and histologic placental inflammation. In all cases, isolated maternal fever and suspected or confirmed intraamniotic infection should be communicated to neonatal caregivers at birth.

Management Prompt initiation of antibiotic therapy is essential to prevent both maternal and fetal complications in the setting of clinical chorioamnionitis [ 2 ]. Variations in practice chorrioamnionitis be warranted when, in the reasonable judgment of the treating clinician, such course of action is indicated by the condition of the patient, limitations of available resources, or advances in knowledge or technology.


Diagnosis and Management of Clinical Chorioamnionitis

Occasionally chorioamnionitis is the result of hematogenous spread of bacterial or viral infection to the placenta. The presence of risk factors of chorioamnionitis, especially membrane rupture, further strengthens the diagnosis.

Bacterial vaginosis and intraamniotic infection. Recent and ongoing clinical research into better methods for diagnosing, treating and preventing chorioamnionitis is likely to have a substantial impact on short and long-term outcomes in the neonate. Chorioamnionitis, infection, pregnancy, management. However, their utility for the diagnosis or prediction of choriamnionitis as part of routine clinical practice is not established.

Adverse maternal outcomes include postpartum infections and sepsis while adverse infant outcomes include stillbirth, premature birth, neonatal sepsis, chronic lung disease and brain injury leading to cerebral palsy and other neurodevelopmental disabilities. Maternal fever even in the absence of documented fetal acidosis is associated with adverse neonatal outcomes, particularly neonatal encephalopathy, though it is unclear to what extent the etiology of the fever rather than the fever itself is causative [ 88 ].

Decreases in non-group B streptococcal neonatal infections also have been noted 9— Medications such as ephedrine, antihistamines, and beta agonists may raise maternal or fetal heart rate. Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: A marker for peripartum infection. The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity. In Januarythe Eunice Kennedy Shriver National Institute of Child Health and Human Development invited an expert panel to a workshop to address numerous knowledge gaps and to provide evidence-based guidelines for the diagnosis and management of pregnant women with what had been commonly called chorioamnionitis and the neonates born to these women.

It should be recognized that many of these proposed risk factors also are associated with longer duration of labor and membrane rupture, and may not be independently associated with intraamniotic infection.

In some settings, this approach may result in increased awareness and diagnosis of intraamniotic infection, which will affect subsequent management of newborns.

The optimal antibiotic regimen for treatment of clinical chorioamnionitis has not been well-studied and current recommendations are based largely on clinical consensus [ 83 ].